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Heart Disease  

Today in the United States, congestive heart failurethe ineffective pumping of the heart caused by the loss or dysfunction of heart muscle cellsafflicts 4.8 million people, with 400,000 new cases each year. One of the major contributors to the development of this condition is a heart attack, known medically as a myocardial infarction, which occurs in nearly 1.1 million Americans each year. It is easy to recognize that impairments of the heart and circulatory system represent a major cause of death and disability in the United States .

Heart attacks and congestive heart failure remain among the Nation's most prominent health challenges despite many breakthroughs in cardiovascular medicine. In fact, despite successful approaches to prevent or limit cardiovascular disease, the restoration of function to the damaged heart remains a formidable challenge.

Recent research is providing early evidence that adult and embryonic stem cells may be able to replace damaged heart muscle cells and establish new blood vessels to supply them. For those suffering from common, but deadly, heart diseases, stem cell biology represents a new medical frontier.

The potential capability of both embryonic and adult stem cells to develop into these cells types in the damaged heart is now being as part of a strategy to restore heart function to people who have had heart attacks or have congestive heart failure. More evidence for potential stem cell-based therapies for heart disease is provided that showed that human adult stem cells taken from the bone marrow are capable of giving rise to vascular endothelial cells.

Stem cells may well serve as the foundation upon which a future form of "cellular therapy" is constructed.


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